Gliomas are a central nervous system neoplasms derived from glial cells and comprise astrocytoma, ependymoma, glioblastoma multiforme and oligodendrogliomas. Oligodendroglioma is the second most common malignant brain tumour in adults and frequently shows characteristic co-deletion of the chromosomal arms 1p and 19q.
This P088-C1 probemix can be used to detect the loss of chromosome arms 1p and 19q in DNA samples obtained from glioma patients, as well as copy number changes in CDKN2A and CDKN2B genes. Furthermore, this probemix contains mutation-specific probes for the most common point mutations of IDH1 and IDH2 genes in gliomas. In addition, 14 reference probes have been included in this probemix, detecting different autosomal chromosomal locations, which are relatively quiet in glioma.