MODY I And II

 

MODY I and II

Maturity-Onset Diabetes of the Young (MODY) is a distinct form of non insulin-dependent diabetes mellitus (NDDM), also known as type II diabetes. MODY has a clear autosomal inheritance and it generally develops in individuals under 25 years of age. Approximately 5% of all diabetes patients suffer from MODY. As described in more detail on page 2, eleven forms of MODY have now been identified with the highest prevalence for MODY 2 and 3. Each form of MODY has been associated with one gene.

 

This P241-D2 MODY probemix contains probes for GCK, HNF1A, HNF1B and HNF4A genes and is therefore specific for MODY 1, 2, 3 and 5. A total of 42 probes are present for these four genes. In addition, 8 reference probes are included in this probemix, detecting 8 different autosomal chromosomal locations.

 

P357-A1 MODY mix 2 probemix contains probes for the PDX1, HNF1B, NEUROD1, KLF11, CEL, PAX4 and INS genes. This probemix is therefore specific for MODY 4 and MODY 6-10. In addition, 10 reference probes are included in this probemix, detecting 10 different autosomal chromosomal locations.